Moving Object Bioassay (MOB)

This laboratory assay was developed by Insect Services and produces very reliable results. Using this test system we can detect both repellent activity at a distance (i.e. via the olfactory route) and upon direct contact simultaneously. The highly standardized test procedure renders the MOB particularly suitable for comparative investigations, such as direct comparison of products or evaluation of dose-response relationships. In addition, products or ingredients not (yet) suitable for humans testing can be evaluated, for example products in an early phase of development. The main advantage of the MOB as compared to other laboratory assays, is that the results are highly reliable, since they closely mirror data collected using human volunteers (Dautel et al., 2013). Lastly, if repellents also show an acaricidal effect, the relationship between contact time with the repellent and mortality rates can be examined.

Typical applications for the MOB test are:

  • Direct comparison of products, ingredients or formulations
  • Evaluation of dose-response curves

Experimental setup with a rotating drum
Fig. 1: Experimental setup with a rotating drum.

A tick transferring from a glass rod to the rotating drum
Fig. 2: A tick transferring from a glass rod to the rotating drum.

Video: A tick transferring from a glass rod to the rotating drum.